Vulnerability · Published Mar 18, 2026 · Assigned by GitHub_M

CVE-2026-31969HTSlib CRAM decoder has a heap buffer overflow

High 7.1

In plain English

A high-severity heap buffer overflow in htslib from samtools. There are no confirmed reports of exploitation so far. The chance it is exploited in the next 30 days is estimated at 0.4% (higher than 30% of all known vulnerabilities). Fixed versions are available - upgrade the affected package.

Severity (CVSS 4.0)7.1High
Exploit odds (30 days)0.4%top 70.5% of all CVEs
Exploited in the wildNo reportsCISA SSVC: none
Attack toolingNoneno public tooling known

Official description

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. When reading data encoded using the `BYTE_ARRAY_STOP` method, an out-by-one error in the `cram_byte_array_stop_decode_char()` function check for a full output buffer could result in a single attacker-controlled byte being written beyond the end of a heap allocation. Exploiting this bug causes a heap buffer overflow. If a user opens a file crafted to exploit this issue, it could lead to the program crashing, or overwriting of data and heap structures in ways not expected by the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Affected packages & fixed versions

EcosystemPackageFixed inAdvisory
Debian:12htslibno fix listedDEBIAN-CVE-2026-31969
Debian:13htslibno fix listedDEBIAN-CVE-2026-31969
Debian:14htslib1.24-2DEBIAN-CVE-2026-31969
Ubuntu:22.04:LTShtslibno fix listedUBUNTU-CVE-2026-31969
Ubuntu:24.04:LTShtslibno fix listedUBUNTU-CVE-2026-31969
Ubuntu:25.10htslibno fix listedUBUNTU-CVE-2026-31969
Ubuntu:26.04:LTShtslibno fix listedUBUNTU-CVE-2026-31969
Ubuntu:26.10htslibno fix listedUBUNTU-CVE-2026-31969

Affected products (as reported)

VendorProductVersions
samtools htslib < 1.21.1>= 1.22, < 1.22.2= 1.23

Weakness: CWE-122, CWE-787 · Vector: CVSS:4.0/AV:N/AC:L/AT:N/PR:N/UI:P/VC:N/VI:H/VA:L/SC:N/SI:N/SA:N

References