Vulnerability · Published Sep 17, 2026 · Assigned by GitHub_M

CVE-2026-54604OpenSlide: openslide_read_region() returns uninitialized memory with libtiff 4.7.1

Medium 5.3

In plain English

A medium-severity security flaw in openslide from openslide. There are no confirmed reports of exploitation so far. The chance it is exploited in the next 30 days is estimated at 0.5% (higher than 45% of all known vulnerabilities). Fixed versions are available - upgrade the affected package.

Severity (CVSS 4.0)5.3Medium
Exploit odds (30 days)0.5%top 55.2% of all CVEs
Exploited in the wildNo reportsCISA SSVC: none
Attack toolingNoneno public tooling known

Official description

OpenSlide is a C library for reading whole slide image files. Prior to 4.0.1, a behavior change in libtiff 4.7.1 causes the indirect TIFF tile path in src/openslide-decode-tiff.c and _openslide_tiff_read_tile() to request a full-height destination for a partial bottom tile row, allowing uninitialized heap memory to enter pixel data returned by openslide_read_region(). A crafted but valid slide can trigger the issue in TIFF-based formats other than Hamamatsu NDPI when a network service renders attacker-provided slides. Successful extraction depends on pixel transparency handling and recompression, OpenSlide with libtiff 4.7.0 or earlier is not affected, and official binary builds 4.0.0.10 and 4.0.0.11 are affected. This issue is fixed in OpenSlide 4.0.1 and official binary build 4.0.0.12.

Affected packages & fixed versions

EcosystemPackageFixed inAdvisory
Debian:12openslideno fix listedDEBIAN-CVE-2026-54604
Debian:13openslideno fix listedDEBIAN-CVE-2026-54604
Debian:14openslide4.0.1+dfsg-1DEBIAN-CVE-2026-54604
Ubuntu:22.04:LTSopenslideno fix listedUBUNTU-CVE-2026-54604
Ubuntu:24.04:LTSopenslideno fix listedUBUNTU-CVE-2026-54604
Ubuntu:25.10openslideno fix listedUBUNTU-CVE-2026-54604
Ubuntu:26.04:LTSopenslideno fix listedUBUNTU-CVE-2026-54604
Ubuntu:26.10openslideno fix listedUBUNTU-CVE-2026-54604

Affected products (as reported)

VendorProductVersions
openslide openslide < 4.0.1

Weakness: CWE-758, CWE-908 · Vector: CVSS:4.0/AV:N/AC:L/AT:N/PR:L/UI:N/VC:L/VI:N/VA:N/SC:N/SI:N/SA:N

References