Vulnerability · Published Sep 27, 2026 · Assigned by VulnCheck

CVE-2026-100845MONAI before 1.6.0 Remote Code Execution via NumpyReader

High 7.8

In plain English

A high-severity unsafe deserialization in MONAI from Project-MONAI. Proof-of-concept exploit code is public. The chance it is exploited in the next 30 days is estimated at 0.2% (higher than 10% of all known vulnerabilities). Fixed versions are available - upgrade the affected package.

Severity (CVSS 3.1)7.8High

Exploit odds (30 days)0.2%top 89.7% of all CVEs

Exploited in the wildNo reportsCISA SSVC: poc

Attack toolingNoneno public tooling known

Official description

MONAI before 1.6.0 contains an unsafe deserialization vulnerability in the NumpyReader class that unconditionally uses numpy.load with allow_pickle=True when loading .npy and .npz files. Attackers can craft malicious .npy files with pickle payloads that execute arbitrary code when loaded through MONAI's standard data pipeline.

Affected packages & fixed versions

Ecosystem	Package	Fixed in	Advisory
PyPI	monai	1.6.0	GHSA-wg9g-w2j2-8pgr
PyPI	monai	1.6.0	PYSEC-2026-4020

Affected products (as reported)

Vendor	Product	Versions
Project-MONAI	MONAI	0 – before 1.6.0

Weakness: CWE-502 · Vector: CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H

References

GitHub Security Advisory (GHSA-wg9g-w2j2-8pgr) vendor-advisory
VulnCheck Advisory: MONAI before 1.6.0 Remote Code Execution via NumpyReader third-party-advisory