Vulnerability · Published Dec 18, 2025 · Assigned by mitre
CVE-2025-68463
Medium 4.9
In plain English
A medium-severity XML external entity in Biopython from Biopython. There are no confirmed reports of exploitation so far. The chance it is exploited in the next 30 days is estimated at 0.3% (higher than 25% of all known vulnerabilities). Fixed versions are available - upgrade the affected package.
Severity (CVSS 3.1)4.9Medium
Exploit odds (30 days)0.3%top 75.4% of all CVEs
Exploited in the wildNo reportsCISA SSVC: none
Attack toolingNoneno public tooling known
Official description
Bio.Entrez in Biopython through 186 allows doctype XXE.
Affected packages & fixed versions
| Ecosystem | Package | Fixed in | Advisory |
|---|---|---|---|
| Debian:12 | python-biopython | no fix listed | DEBIAN-CVE-2025-68463 |
| Debian:13 | python-biopython | no fix listed | DEBIAN-CVE-2025-68463 |
| Debian:14 | python-biopython | 1.87+dfsg-1 | DEBIAN-CVE-2025-68463 |
| PyPI | biopython | no fix listed | GHSA-x3vf-39hj-gxr4 |
| PyPI | biopython | 1.87 | PYSEC-2026-1221 |
| Ubuntu:22.04:LTS | python-biopython | no fix listed | UBUNTU-CVE-2025-68463 |
| Ubuntu:24.04:LTS | python-biopython | no fix listed | UBUNTU-CVE-2025-68463 |
| Ubuntu:25.10 | python-biopython | no fix listed | UBUNTU-CVE-2025-68463 |
| Ubuntu:26.04:LTS | python-biopython | no fix listed | UBUNTU-CVE-2025-68463 |
| Ubuntu:26.10 | python-biopython | no fix listed | UBUNTU-CVE-2025-68463 |
Affected products (as reported)
Weakness: CWE-611 · Vector: CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L